A.A. Kremzer.Diagnostic value of brain natriuretic peptide as indicator of ischemic chronic heart failure severity in diabetes mellitus 2 types patients

The aim – to study diagnostic value of NT-pro-BNP plasma level to establish severity of chronic heart failure due to ischemic heart disease depending on concomitant type 2 diabetes mellitus. Eighty two patients with ischemic chronic heart failure have been included into the study. It was shown that circulating level of NT-pro-BNP reflects heart failure severity at excess of cut-off point value 1272.45 fmol/ml (sensitivity 88.6 %, specificity 72.3 %, the positive likelihood ratio 6.15; the negative likelihood ratio 0.16) in patients with chronic heart failure and type 2 diabetes mellitus. At lower concentrations NT-pro-BNP may reflect presence of other reasons potentially modulating exaggerated cardiovascular risk, such as: type 2 diabetes mellitus, proinflammatory activation, atherosclerotic lesions of coronary arteries, hyperlipidemia and regional left ventricular dysfunction.

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