The aim – to determine changes of cardiovascular system and neurohumoral regulation at early stages of chronic heart failure (CHF) in children and adolescents with different myocardial pathologies.
Material and methods. There have been examined 208 adolescents at the age of 12–18 years with different myocardium pathologies: 54 after myocarditis and 154 with dysplastic cardiopathies. Control group consisted of 68 apparently healthy peers. Morphofunctional, general haemodynamics parameters, diurnal urinary excretion of catecholamines, plasma renin activity, angiotensin-II and aldosterone, IL-1β and IL-6 cytokines, TNF-α and apoptosis factor СD95/Fas levels in blood serum have been studied.
Results. It has been established that adolescents with myocardial inflammatory and noninflammatory pathology manifested heart contractility disorders in both ventricles, in some cases detected with exercise testing only. Such manifestations have been accompanied by highly increased activation of neurohumoral systems (sympathoadrenal and renin-angiotensin-aldosterone), increase of antiinflammatory cytokines level and СD95/Fas frequency.
Conclusion. Obtained data provide pathogenetic basis for usage of neurohumoral activation blockers in adolescents with subclinical manifestations of heart failure.