The article focuses on actual problems of occupational health and genetics aiming to improve the existing system of primary prevention of cardiovascular disease (CVD) in coal miners in Ukraine, by identifying genetic markers of genetic predisposition to the development of left ventricular hypertrophy. The purpose of investigation was to develop contemporary methods of primary prevention of left ventricular hypertrophy in CVD in the coal miners. Fourty six hypertensive coal miners and 47 healthy coal miners controls were enrolled into the study. All patients had more than 5-years experience of underground work. The study revealed one variant of combination of allelic polymorphisms of genes AGT, AT1R, GNB3, EDN1, MTHFR, one of which was associated with predisposition to development to left ventricular hypertrophy. It was established that AGT*TT genotype was a risk factor for development of left ventricular hypertrophy (χ2=13.84; Р≤0.0001). Genotypes associated with development of left ventricular hyp ertrophy were AGT*ТТ, AT1R*СС, GNB3*ТТ, GNB3*СТ і EDN1*ТТ. On the contrary, AT1R*АС, AT1R*АА, GNB3*СС, EDN1*GТ, EDN1*GG і MTHFR*АА genotypes were not related to the development of left ventricular hypertrophy. The study of genetic structure of the population and search for molecular genetic markers of risk for CVD is considered a most promising was to the CVD prevention.