O.I. Mitchenko, A.S. Lavrik, A.O. Shkroba, V.Yu. Romanov.Effect of medical and surgical treatment of obesity on structural and functional parameters of left ventricle in patients with morbid obesity and arterial hypertension

The aim – to study the structural and functional parameters of left ventricle in patients with morbid obesity and arterial hypertension before and 6 months after conservative and surgical treatment of obesity. Material and methods. We examined 164 patients with morbid obesity (BMI > 40 kg/m2), they formed two groups. The first group included 81 patients who treated obesity with diet and drug Stifimol. The second group included 83 patients who underwent bariatric surgery (gastric banding or gastric bypass surgery). Patients were examined before and 6 months after treatment of obesity. All patients underwent clinical examination, determination of anthropometric parameters, cardiac ultrasound to determine the index of left ventricular mass. Results. 6 months after treatment, in first and second groups weight and BMI were significantly reduced. Body weight was reduced by 5.5 kg (4.6 %) and 35 kg (22.8 %) in the first and second group, respectively. As a result, in the first group thickness of the interventricular septum decreased by 4.3 %, PWLV – by 1.9 %, LVM – by 6 %, LVMI1 and LVMI2 – by 4 and 6 %, in the second group IVS thickness was reduced by 8.2 %, PWLV – by 4.3 %, LVM – by 21 %, LVMI1 and LVMI2 – by 12 and 21 %. Conclusions. Weight loss was achieved under drug therapy and after surgery. Significant reduction of the body weight was observed in patients of the second group. It was associated with significant structural and functional changes of left ventricle

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