V.I. Tseluyko, T.A. Lozovaya.Galectin-3 and state of cardiac remodeling in patients with myocardial infarction of the right ventricle due to infarction of the posterior wall of the left ventricle

The aim – to evaluate the galectin-3 levels and cardiac hemodynamics in the patients with myocardial infarction (MI) of the right ventricle (RV) due to MI of the posterior wall of the left ventricle (PW LV).
Material and methods. 148 patients with acute MI of the PW LV aged 61.16±0.76 years were examined. 62 patients were included into the I group with MI of PW LV and the involvement of RV, the II group included 86 patients with isolated MI of PW LV. Echocardiography was performed on 4–5 day of acute MI. Galectin-3 levels were determined at baseline using enzyme-linked immunosorbent assay kit (Austria).
Results. The levels of galectin-3 in patients with RV MI (28.38±0.86 ng/ml) were significantly higher (26.6 %, Р<0.05) than in patients with MI of PV LV (22.41±0.49 ng/ml). Cardiac parameters of RV in patients of the I group were characterized by significant increase of right atrium (RA) (8.1 %), diameter of RV (DRV) (8.7 %), DRV/end-diastolic diameter (EDD) of LV (10.4 %) and the reduction the contractile ability of RV (18.1 %) in comparison to isolated MI of PWLV (Р<0.05). The level of galectin-3 in patients with RV MI correlated with the severity of acute HF (r=0.66; Р<0.01), troponin levels (r=0.55; Р<0.01) and creatinine concentration (0.45; Р<0.05). Galectin-3 concentration was associated with size of the left atrium, and the RA (r=0.59, r=0.67; Р<0.01), the diameters of LV (r=0.87, r=0.86; Р<0.01), DRV (r=0.53; Р <0.01), and with decrease of the LV ejection fraction (r=–0.38; Р<0.05). Concentration of galectin-3 was associated with prognosis of the patients with RV MI, which was calculated by the scales TIMI (r=0.57; Р<0.01) and GRACE (r=0.43; Р<0.05). Conclusions. The data indicate on the diagnostic potential prospects galectin-3 levels as an additional criterion for assessing the severity and prognosis cardiac remodeling in patients with RV MI.

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