M.Yu. Sokolov, M.I. Studzinskaya.Acute coronary syndromes without sustained ST elevation: peculiarities of interventional therapy.

The purpose of this study was to assess the effectiveness of the coronary stenting in patients with acute coronary syndromes without sustained ST elevation (NSTE-ACS) and morphological and functional state of the myocardium and coronary vessels, as well as time of symptoms onset. The study included 101 NSTE-ACS patients who were divided into three groups: Group 1 consisted of patients who underwent coronary stenting (CS), Group 2 – patients who did not undergo revascularization procedures (control group), and Group 3 – patients who underwent surgical revascularization (CABG). Overall survival of NSTE-ACS patients at different time points after beginning of symptoms was significantly better for patients who underwent CS, Р<0.0048. Patients that underwent CS had better exercise capacity, less likely recurrence of angina and myocardial infarction. Over 48 months the overall survival in stented patients was 95 %, in the control group – 80 %. The cumulative survival rate for NSTE-ACS patients which were electively stented during period from 4 to 180 days, with no MACE, was significantly higher in comparison with the control group, Р<0.0036. After 48 months of follow-up, number of patients without disturbances of segmental contractility increased from 82.4 to 92.4 %. An area of regional hypokinesia remained in only 6.8 % of patients (initially 16.5 %). Thus, CS is an effective method of treatment of NSTE-ACS patients with various morphological and functional states of the myocardium and coronary vessels and with different time of symptoms onset.

Full article