Ye.V. Andryeyev, Yu.M. Makukha Gene polymorphism of folate metabolism in patients with myocardial infarction: results of studying in the Ukrainian population

The aim – to determine the prevalence of gene polymorphism of folate metabolism in patients with myocardial infarction (MI) compared to healthy subjects in Ukraine.

Material and methods. The study involved 51 male, age up to 50 years (mean 43.21±2.8 yrs), who survived myocardial infarction in 2011–2014. The control group consisted of 35 male subjects, having no significant differences regarding age, smoking and hereditary history.

Results. The study of gene polymorphism revealed heterozygous type MTHFR 677 CT in 29 (56.9 %) patients with MI and 12 (34.3 %) healthy individuals (P<0.05), heterozygote MTHFR 1298 AS – in 25 (49.0 %) patients and 9 (25.7 %) healthy subjects (P<0.05). Conclusions. Higher prevalence of gene polymorphism of MTHFR, MTR 2756, MTRR 66 among young survivors of myocardial infarction indicates the possible effect of folate metabolism disorders in the pathogenesis of myocardial infarction at a young age. The presence of genetic susceptibility significantly increases the risk of MI in this group of patients.

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