Author Archives: admin

O.I. Deltsova, S.B. Geraschenko, Yu.B. ChaikovskyStem cells of the blood vessels wall.

Ivano-Frankivsk National Medical University, Ukraine
O.O. Bogomolets National Medical University, Kyiv, Ukraine
The review of literature is devoted to results of blood vessels wall stem cells (smooth muscle cells, endotheliocytes) investigation. Contemporary view on the structure components of stem niches, markers and transcriptional factors of the smooth muscle cells and endotheliocytes and their participation in remodeling of blood vessel wall are presented. Data on stem cells and progenitor cells circulating in blood, their age changes and their role in pathogenesis of cardiovascular diseases are discussed.

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F.M. Abduyeva, E.Yu. Shmidt, N.Y. YabluchanskiyVentricular extrasystoles in pregnant women.

V.N. Karazin Kharkiv National University, Ukraine
Central Clinical Hospital “Ukrzaliznytsya”, Kharkіv, Ukraine
The article presents a literature review of the contemporary data on the etiology, pathogenesis, classification, and treatment of ventricular extrasystoles in pregnant women. A clinical case of pregnant patient with premature ventricular contractions is considered in terms of the described algorithm for evaluation of the clinical significance of this type of arrhythmia.

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E.F. Barinov, O.N. Sulaieva, N.N. Kanana, K.I. GatinaMolecular mechanisms of functioning and role of P2Y1 and P2Y12 receptors in thrombogenesis.

M. Gorky Donetsk National Medical University, Ukraine
The role of purine platelet receptors (P2Y1 and P2Y12) in thrombogenesis under normal conditions and in cardiovascular pathology is reviewed. The intracellular signaling mechanisms associated with P2Y1 and P2Y12 receptors and biological effects of purines (ADP) on platelets are discussed. The role of genetic polymorphism, receptor sensitivity and mechanisms of receptor desensitization in platelet reactivity are addressed.

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Prepared S.M. Kozhukhov.European Congress of Cardiology – 2013.

Important advances have been made in the past few years in the fields of clinical cardiac electrophysiology and pacing. Researchers and clinicians have a greater understanding of the pathophysiological mechanisms underlying atrial fibrillation (AF), which has transpired into improved methods of detection, risk stratification, and treatments. The introduction of novel oral anticoagulants has provided clinicians with alternative options in managing patients with AF at moderate to high thromboembolic risk and further data has been emerging on the use of catheter ablation for the treatment of symptomatic AF. Another area of intense research in the field of cardiac arrhythmias and pacing is in the use of cardiac resynchronisation therapy (CRT) for the treatment of patients with heart failure. Following the publication of major landmark randomised controlled trials reporting that CRT confers a survival advantage in patients with severe heart failure and improves symptoms, many subsequent studies have been performed to further refine the selection of patients for CRT and determine the clinical characteristics associated with a favourable response. The field of sudden cardiac death and implantable cardioverter defibrillators also continues to be actively researched, with important new epidemiological and clinical data emerging on improved methods for patient selection, risk stratification, and management. This review covers the major recent advances in these areas related to cardiac arrhythmias and pacing.

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R. Liew.Almanac 2013: cardiac arrhythmias and pacing.

Important advances have been made in the past few years in the fields of clinical cardiac electrophysiology and pacing. Researchers and clinicians have a greater understanding of the pathophysiological mechanisms underlying atrial fibrillation (AF), which has transpired into improved methods of detection, risk stratification, and treatments. The introduction of novel oral anticoagulants has provided clinicians with alternative options in managing patients with AF at moderate to high thromboembolic risk and further data has been emerging on the use of catheter ablation for the treatment of symptomatic AF. Another area of intense research in the field of cardiac arrhythmias and pacing is in the use of cardiac resynchronisation therapy (CRT) for the treatment of patients with heart failure. Following the publication of major landmark randomised controlled trials reporting that CRT confers a survival advantage in patients with severe heart failure and improves symptoms, many subsequent studies have been performed to further refine the selection of patients for CRT and determine the clinical characteristics associated with a favourable response. The field of sudden cardiac death and implantable cardioverter defibrillators also continues to be actively researched, with important new epidemiological and clinical data emerging on improved methods for patient selection, risk stratification, and management. This review covers the major recent advances in these areas related to cardiac arrhythmias and pacing.

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O.Ye. Yadlovskyi, T.A. Bukhtiarova.The effect of a new non-opioid analgesic pirodazol on hemodynamics of rats.

The effect of a new non-opioid analgetic drug pirodazol upon hemodynamic parameters was studied as aspect of safety pharmacology. The study was conducted on white rats. Pirodazol was administered intramuscularly in doses of 1/20 LD50, 1/4 LD50, 1/2 LD50 (1,1; 5,5 and 11 mg kg respectively). Dose-related specific hemodynamic changes were elicited starting from the 30th min after single pyrodazol injection administration. Maximal hypotensive effect (up to -51.66 %) was achieved at the dose of 11 mg/kg. The hypotensive effect was accompanied by compensatory tachycardia, decreased cardiac output (up to –62.8 %) and systemic vascular resistance (up to –30.6 %). At a dose of 1.1 mg/kg hemodynamic changes were not significant, apart from changes of total peripheral vascular resistance at 30 and 60 min after administration.

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S.V. Shevchuk, Y.S. Seheda.Cardiovascular risk stratification in patients with antiphospholipid syndrome.

There is strong evidence that patients with antiphospholipid syndrome have an increase risk of early development of cardiovascular events with resulting mortality. However, the existence of specific mechanisms of atherogenesis in antiphospholipid syndrome may affect cadiovascular risk assessment. The main purpose of this study was to evaluate the risk of coronary events by the most common rating scales, to compare it with traditional and specific risk factors and to investigate correlation of individual risk of vascular lesions with its actual state. The study included 77 patients with antiphospholipid syndrome and 37 age- and sex-matched healthy subjects. Traditional risk factors such as dyslipidemia, obesity, arterial hypertension age, sex, diabetus mellitus, sedentary lifestyle were assessed in each participant. State of the cardiovascular system was evaluated on the basis of laboratory and instrumental examination. To identify patients with silent myocardial ischemia daily ECG monitoring was used. We investigated plasma levels of total cholesterol, triglycerides, high-density lipoprotein, TNF-α, CRP, paraoxanase activity, IL-1, anticardiolipin antibodies IgG and anti-b2-glycoprotein antibodies. In addition, we evaluated flow-mediated vasodilation of brachial artery, assessed thickness of intima-media complex of the common carotid artery and the presence of atherosclerotic plaques in the common carotid artery. Risk stratification of cardiovascular events was performed by using Framingham, SCORE and Reynolds scales. Individual risk of cardiovascular lesions in patients with antiphospholipid syndrome was 1.65–2.78 times higher than in the general population. Significant differences of the cardiovascular risk measured by different scales were established: 39 % high risk individuals have been registered by SCORE scale, compared to 14.3 % patients by Framingham and 20.8 % patients by Reynolds scale. The main factors increasing individual cardiovascular risk in patients with antiphospholipid syndrome were dyslipidemia, high blood pressure, male gender, diabetes mellitus and smoking. SCORE scale does not reflect the real state of the cardiovascular system in patients with antiphospholipid syndrome, estimated by instrumental methods. In conclusion, it is necessary to develop new algorithms of cardiovascular risk assessment in patients with antiphospholipid syndrome based on the specific risk factors.

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G.S. Isayeva, A.V. Martynenko, V.I. Volkov. Cardiovascular risk and it relation to hormonal state in perimenopausal women.

The present paper is dedicated to the problem of cardiovascular risk assessment in perimenopausal women. The special importance is given to understanding of woman hormonal balance impact, measured by the level of folliculi stimulating hormone. In a cross-sectional study 219 patients without coronary heart disease were included. In order to assess cardiovascular risk, SCORE scale was used. Cardiovascular risk was low or moderate in the majority of examined women. It was found that folliculi stimulating hormon had a most prominent impact upon cardiovascular risk in women 60–65 years old.

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