L.M. Babii, N.P. Stroganova, Yu.O. Khomenko Left ventricular diastolic dysfunction and its role in the development of heart failure in patients with ischemic artery disease

The aim – to study left ventricular (LV) diastolic function and role of diastolic dysfunction in the development of heart failure in patients with ischemic artery disease.

Material and methods. One hundred and twenty-nine patients with coronary artery disease were included: the 1st group (n=42) – pts with CAD and normal systolic function of LV; the 2nd (n=56) pts who had survived myocardial infarction 1–2 years ago with normal ejection fraction, stroke volume but with decreased diastolic function and increased end-systolic volume; the 3rd (n=36) pts with ischemic artery disease and heart failure IIA stage; the control group (n=26) – healthy volunteers. Equilibrium cardio synchronized radionuclide ventriculography with 99mTc-pyrophosphate was performed in all patients.

Results. The obtained data indicate at uniformity of changes in diastolic indexes volumes but differences in there extension. In pts of the 1st group reduction of diastolic function was combined with normal systolic indexes; in pts of the 2nd group diastolic dysfunction was combined with early signs of systolic function; in pts with heart failure changes in diastolic indexes were more severe compared to the pts of the 1st and 2nd groups.

Conclusions. Diastolic dysfunction in pts with ischemic artery disease and normal systolic function may be defined as an early phase of LV function changes; in pts of the 2nd group combination of more severe changes of LV diastolic function with early and less expressed signs of systolic dysfunction may be defined as a mainly diastolic dysfunction; in pts of the 3rd group combination of more expressed changes of systolic function with less expressed changes in diastolic indexes may be defined as mainly systolic dysfunction.

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