V.О. Serhiyenko.Cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus: N-tеrminal brain natriuretic peptide and structural-functional myocardial disorders.

The aim of the study was to examine N-tеrminal brain natriuretic peptide (NT-prоBNP), corrected QT interval and QT interval dispersion, parameters of structure and function of myocardium in patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy (CAN). The study involved 77 patients with type 2 diabetes mellitus, including 15 patients without verified cardiovascular disease, 18 patients with subclinical stage CAN, 19 – functional, 25 – functional-organic stage CAN. Control group included 17 healthy subjects. It was established, that the increase of the NT-proBNP concentration in patients with type 2 diabetes mellitus may indicate a presence of subclinical CAN, which is often not established using traditional diagnostic methods. Increased concentration of NT-proBNP is correlated with presence and/or progression of CAN; statistically significantly and independently correlated with prolongation and dispersion of QT interval. Increased NT-proBNP concentration is significantly and independently associated with increased left ventricular mass in patients with type 2 diabetes mellitus. These results suggest the relation between structural, functional and electro-mechanical disturbances in patients with type 2 diabetes mellitus and CAN.

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