The present paper is dedicated to the problem of cardiovascular risk assessment in perimenopausal women. The special importance is given to understanding of woman hormonal balance impact, measured by the level of folliculi stimulating hormone. In a cross-sectional study 219 patients without coronary heart disease were included. In order to assess cardiovascular risk, SCORE scale was used. Cardiovascular risk was low or moderate in the majority of examined women. It was found that folliculi stimulating hormon had a most prominent impact upon cardiovascular risk in women 60–65 years old.