V.Р. Chyzhova Influence of intermittent hypoxia training on microcirculatory system, glucose homeostasis and lipids in prediabetes patients 60 years age and over

The aim – to understand effects of intermittent hypoxia training (IHT) in prediabetes patients 60 years age and over on microcirculatory system, glucose homeostasis and lipids.

Material and methods. A total of 82 subjects of different age were included into this analysis. All of them underwent glucose tolerance test (GTT). After GTT 19 prediabetes people 60 years age and over continued investigation with determination of plasma glucose, insulin and cortizol. Insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-ІR). Lipid profile, endothelial function and microcirculatory system were studied before and after IHT in prediabetes patients 60 years age and over.

Results. It was shown that IНT promotes the normalization of carbohydrate metabolism in the elderly prediabetes people. Favorable changes were observed after the IHT course: the percentage of people with pre-diabetic disorders decreased from 100 % to 42.1 % (Р<0.01). One month after the IHT, an increase in the normalizing effect on the carbohydrate metabolism was noted: a statistically significant decrease in the fasting glucose from 5.8±0.2 to 5.5±0.2 mmol/l (Р<0.05), after 2 hours GTT – from 8.5±0.2 to 7.0±0.4 mmol/l (Р<0.01). Pre-diabetic disorders were detected in 15.8 % of the subjects (Р<0.001) after 1 month of IHT. In prediabetes subjects after course use of IHT there was statistically significant decrease in total cholesterol and cholesterol of low density lipoproteins. Conclusions. The use of IHT is promising for correction of prediabetes disorders in the elderly, which reduces not only the risk of developing type 2 diabetes but also prevents cardiovascular complications.

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