L.N. YakovlevaCombined antihypertensive therapy: focus on fixed combination of enalapril and nitrendipine.

Kharkiv Medical Academy of Postgraduate Education, Ukraine
The problems associated with arterial hypertension, being a powerful, independent and potentially easily detectable and correctable risk factor of fatal cardiovascular events, are reviewed. Despite the development and introduction into clinical practice of highly effective anti-hypertensive medications, adequate control of blood pressure is achieved in
only 30–50 % of patients. The reasons for this low rate of blood pressure effective control are the difficulty of the target blood pressure achieving with monotherapy and low patients adherence to treatment with several drugs. This review discusses the advantages of antihypertensive medications fixed combinations in general, and the combination of angiotensin-converting enzyme inhibitor enalapril and the dihydropyridine calcium antagonist nitrendipine, in particular. The results of clinical studies showing high efficacy of this fixed combination in achieving target blood pressure, good tolerability, organ-protective properties and positive influence on the prognosis are presented.

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