O.I. Mitchenko, A.O. Logvinenko, V.Yu. Romanov Diurnal profile of blood pressure and structural-functional state of myocardium in patients with metabolic syndrome and thyroid dysfunction, treatment optimization

The aim of the study data was: to study diurnal profile of blood pressure (BP), structural and functional state of myocardium in patients with metabolic syndrome (MS) and subclinical hypothyroidism and the ways to optimize therapy using hormone replacement therapy (HRT). We examined 203 women with hypertension: 134 with hypothyroidism, 21 with hyperthyroidism and 48 euthyroid patients. The examination of patients was conducted
at baseline and after 6 months. The analysis showed increase of 24-hour, day and office diastolic BP and prevalence of adverse daily profiles of “night-peaker” and “non-dipper” in patients with MS and subclinical
hypothyroidism. Subclinical hypothyroidism was associated with formation of left ventricular hypertrophy. Usage of HRT was accompanied by lower diastolic BP in 48 % patients, less prevalence of “non-dipper” profile and
absence of “night-peaker” profile. Within 6 months of observation HRT was associated with regression of left ventricular hypertrophy compared to the patients who received only antihypertensive therapy without HRT

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