Yu.М. Sirenko, G.D. Radchenko, I.M. Martsovenko, on behalf of the study group Experience of treatment of patients with arterial hypertension by the Ukrainian generic drugs

To evaluate possible causes of poor blood pressure (BP) control we followed the results of management of hypertensive patients by general practitioners. We involved 10 158 patients with hypertension from 63 cities of
Ukraine. 531 general practitioners participated in the study. They might treat patients according to their decision, but had to achieve target BP < 140/90 mm Hg. Baseline and 3 months afterwards all patients answered questions regarding lifestyle and performed the Compliance Evaluation Test (CET). BP was measurement every 4 weeks. Among 9062 patients who performed CET at baseline, 23 % had compliance ≥80 %, 33.7 % – 50– 79 % and 43.3 % – < 50 %. At the end of study 32.1 % had compliance ≥80 %, 39.2 % – 50–79 % and 28.7 % – < 50 %. The target BP was achieved only at 58.9 % of patients. Patients who did not achieved target BP were older, had higher level of BP at baseline, more prevalent history of stroke or myocardial infarction, secondary hypertension, less compliance. They were less educated, less physically active, ate less fresh fruits and vegetables, had more duration and intensity of smoking. We noted significant differences (from 50 to 77 %) regarding achieving target BP in different regions of Ukraine. The adverse events were registered in 9.1 %. In conclusion, in planned evaluation of AH treatment the control of BP was significantly better, than in epidemiological studies. The reasons for worse BP control were low compliance, more severe hypertension, elderly age, history of complications, lower lifestyle modification. During the treatment the risk of fatal and non-fatal cardiovascular event development decreased from 19.1 and 5.7 % to 14.3 and 4.2 %, accordingly

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