I.V. MartynivDose-dependent hypotensive and renoprotective effect of atorvastatin in patients with arterial hypertension

The effect of atorvastatin on blood pressure, lipid profile and level of microalbuminuria (MAU) was studied in 138 patients in stage II hypertension (70 patients with essential hypertension and 68 patients with symptomatic renoparenchimal arterial hypertension). In addition to pronounced lipid-lowering effect, atorvastatin has hypotensive and renoprotective effect manifested by further reducing MAU in patients against background of hypotensive therapy. These properties of the drug are pleiotropic, because are not related to reduction of serum lipids and occur with prolonged (more than 6 months) use of atorvastatin in a dose of 20 mg daily

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