G.V. Dzyak, E.L. Kolesnik. Arterial wall stiffness in male patients with arterial hypertension, depending on age

The aim – tThe aim – to investigate age features of arterial wall stiffness in hypertensive patients.

Material and methods. Ninety male patients with essential hypertension stage I and II, aged 18–69 years, were included. At the moment of inclusion all patients were not treated by antihypertensive or lipid-lowering drugs. Subjects were divided by age decade into groups. Peripheral blood pressure (BP) and arterial wall stiffness parameters have been measured.

Results. Linear increasing of the central systolic BP (cSBP) and central pulse pressure (cPP) levels, pulse wave velocity (PWV) and augmentation index (Aix) values along with age was registered. PWV levels in all age groups exceeded currently existing reference values for hypertensive patients. The most significant associations were identified between age and cSBP (r=0.58; Р<0.05), cPP (r=0.49; Р<0.05), AIx (r=0.69; Р<0.05) and PWV (r=0.56; Р<0.05) in the aorta. PWV was highly related to the office systolic BP and diastolic BP at the age of 40, and met criteria for subclinical lesion of the vascular wall as a target organ at 50 years. PWV was directly associated to increasing of cSBP and cPP in aorta as well. Conclusions. The nature of the identified changes indicates significant increase of the cSBP, cPP and PWV in hypertensive patients at the age of 40–49 years, which reflects deterioration of arterial wall stiffness and magnification of cardiovascular risk.

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