A.M. Shevelok.Effect of omega-3 polyunsaturated fatty acids on bioelectrical activity of the heart in patients with paroxysmal atrial fibrillation

Objective – to evaluate the effect of omega-3 polyunsaturated fatty acids (PUFAs) on bioelectrical activity of the heart in patients with paroxysmal atrial fibrillation (AF).
Materials and methods. The study included 56 patients (44 men and 12 women, mean age 58.6±8,5 years) with moderate arterial hypertension and stable coronary heart disease who had a history of frequent (≥ 1/month) paroxysmal AF and sinus rhythm at the baseline. Patients were divided into two groups: I (n=28) consisted of patients who received only standard therapy within 6 months, in II (n=28) the encapsulated highly purified long-chain omega-3 PUFA 1 g/day were additionally prescribed. At baseline and after 6 months treatment standard electrocardiography, signal-averaged electrocardiography with assessment of atrial late potentials (ALP), 24-h Holter monitoring and transthoracic echocardiography were performed. The AF recurrence rate during 6 months was measured.
Results. After 6 months treatment bioelectric parameters in group I did not significantly change. In group II the P-wave dispersion, the average and maximum heart rate, the mean number of supraventricular and ventricular premature beats, episodes of supraventricular tachycardia and the ALP rate significantly (p<0.05) decreased compared to the baseline. AF recurrences were recorded in 26 (93 %) patients of the group I and in 18 (64 %) patients of the group II (χ2=5,00; р=0,025). Conclusions. Supplementation with omega-3 fatty acids 1 g/day for 6 months in addition to standard anti-arrhythmic therapy in patients with paroxysmal AF is associated with significant decrease in P-wave dispersion, heart rate, heart ectopic activity and atrial fibrillation recurrence.

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