The aim of the research was to study safety and efficiency of fixed combination of lercanidipine and enalapril in routine practice. This was a prospective, open, non-controlled study with 3-months follow-up. The patients received enalapril 20 mg and lercanidipine 10 mg in fixed combination. Office, ambulatory and self-measured blood pressure (BP) levels were measured. In total, 622 patients in the age 61.3±13.3 years were included, among them 54.2% males. Office BP decreased in average by 29.2/14.2 mm Hg, pulse BP – by 15.0±16.4 mm Hg. The number of patients with microalbuminuria decreased from 14.6 to 6.5% (Р<0.001). Side effects were registered in 3.4%. In conclusion, fixed combination of lercanidipine and enalapril was effective and well tolerated, improved parameters of BP and microalbuminuria.