The aim of the study was to evaluate the influence of fixed-dose antihypertensive combination on office, ambulatory and central blood pressure (BP), arterial stiffness, as well as sexual function. There were included 33 patients with moderate and severe arterial hypertension (mean systolic/diastolic blood pressure (SBP/DBP) 167.3±0.8/90.3±0.9 mmHg). We studied body mass index, office and 24-hours ambulatory blood pressure, pulse wave velocity (a. carotis – a. femoralis (PWVe) and a. radialis), performed noninvasive central SBP measurements and pulse wave analysis, laboratory analysis and ECG in all patients. In men the sexual dysfunction was evaluated by international index of erectile function (IIEF) multidimensional scale. Patients were administered fixed combination of valsartan and hydrochlorothiazide 160/25 mg. If target blood pressure was not achieved at 1 month, amlodipine (up-titrated to 10 mg) was added. Therapy decreased office systolic (SBP)/diastolic (DBP) from 167.3±3.5/90.3±2.3 to 130.3±1.1/79.3±1.2 mm Hg. The target office BP was achieved in 60,6 % at 1 month of treatment and in 100 % at the end of study. Central SBP decreased from 135.4±4.5 to 124.3±2.1 mm Hg and arterial stiffness improved. Therapy was metabolic neutral, improved erectile function and total satisfaction in 23.8 % patients, was safe and associated with high patient compliance.