M.I. Lutay, I.P. Golikova, A.F. Lysenko, V.V. Tovstukha.Efficiency of the fixed S-amlodipin and atorvastatin combination for patients with high and very high cardiovascular risk.

Efficiency and good tolerability of the fixed combination of S-amlodipin 2.5 mg with atorvastatin 10 mg during 12-weeks treatment of patients with high and very high cardiovascular risk was demonstrated in the paper. Among very high risk patients, 94 and 33 % patients, accordingly, achieved their blood pressure and low-density lipoproteins cholesterol (50 % reduction) targets, among high risk patients – 92 and 60 %. Patients with coronary artery disease taking 5/20 mg fixed combination showed improvement of exercise tolerance (increase of the average power workload by 20 W and workload duration by 118 sec). Fixed combination of S-amlodipin and atorvastatin was well tolerated: no serious clinical and laboratory side effects were registered.

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