The aim of this study was to evaluate the efficacy of the combined gluconic acid drug usage in addition to amiodarone for restoration of sinus rhythm and prevention of recurrent atrial fibrillation (AF). The treatment results of 86 patients with persistent AF were retrospectively analyzed. The study group (n=54) received potassium and magnesium gluconate medication added to amiodarone. The control group (n=32) did not receive the study drug. The restoration of sinus rhythm was achieved in 56 patients (65.1 %), including 41 patients from the study group (75.9 % of this group) and 15 – from the control group (46.9 %, accordingly). Holter ECG monitoring was performed 3–5 days after sinus rhythm restoration in all patients. The total number of atrial and ventricular extrasystoles didn’t differ significantly in two groups. Yet, compared to the control group, supraventricular couplets and AF episodes were significantly reduced with magnesium/potassium gluconate addition, making possible to suggest lower risk of the recurrent persistent AF. Thus, usage of the combined gluconic acid drug increased efficacy of drug cardioversion with amiodarone in patients with persistent AF. It was associated with lower number of supraventricular couplets and short AF episodes after cardioversion.