K.E. Farsalinos, D. Tsiapras, S. Kyrzopoulos, M. Savvopoulou, V. Voudris. Changes in blood pressure, heart rate and left ventricular diastolic function in acute test with using tobacco-cigarette and electronic nicotine-delivery device

The aim – to examine the immediate effect of electronic cigarette use on look pressure, heart rate and left ventricular diastolic function compared to the well documented acute adverse effect of smoking.
Material and methods. Echocardiographic examination were performed in 36 healthy heavy smokers (SM, age
36±5 years) before and after smoking 1 cigarette and in 40 electronic cigarette users (ECIG, age 35±5 years) before and after using the device with «medium strength» ni opine concentration (11 mg/ml) for 7 minutes. Mitral flow diastolic velocity (E, A), their ratio (E/A), deceleration time (DT), isovolumic reaction time (IVRT) and corrected to heart rate (IVRTc) were, ensured. Mitral annulus systolic (Sm) and diastolic (Em, Am) velocity were estimated. Myocardial performance index was calculated from Doppler flow (MPI). Longitudinal deformation measurements of global strain (GS), systolic (SRs) and diastolic (SRe, SRa) strain rate were also performed.
Results. Baseline measurements were similar in both group. In SM IVRT and IVRTc were prolonged. Em and SRe were decreased, and both MPI and MPIt were elevated after smoking. In EVIG no differences were observed after device use. Comparing after use measurements, ECIG had higher Em (P=0.032) and SRe (P=0.022), and lower IVRTC (P=0.011). MPI (P=0.001) and MPIt (P=0.019). The observed differences were significant eve after adjusting for changes in heart rate and blood pressure.
Conclusion. Although acute smoking causes a delay in myocardial relaxation, electronic cigarette use has no immediate effects. Electronic cigarettes’ role in tobacco harm reduction should be studied intensively in order to determine whether switching to electronic cigarette use may have long term beneficial effect on smokers health.

Full article