L.G. Voronkov, N.G. Gorovenko, I.D. Mazur, I.A. Shkurat, L.S. Mkhitarіan, T.F. Drobotko I/D angiotensin-converting enzyme gene polymorphism and endothelial-dependent vasodilation in chronic heart failure.

The aim of the research was to study relation of endothelial-dependent vasodilation and I/D angiotensinconverting enzyme (ACE) gene polymorphism in chronic heart failure (CHF). Ninety six patients with ischemic
CHF and left ventricular systolic dysfunction (ejection fraction “T 45%) were involved into the study. Flowmediated vasodilation (FMD) of a. brachialis was studied by standard culf test. The ACE activity in blood serum
was measured by spectrofluorimetric methods. It was established that FMD does not depend on polymorphic variants of ACE gene. Blood serum ACE activity was similar in II, ID and DD genotypes of ACE gene polymorphism.

Full article