Yu.M. Sokolov, M.Yu. Sokolov, V.G. Terentiev, I.V. Tarapon, V.Yu. Kobyliak, O.Yu. Sirenko, N.P. Levchuk, O.M. Krot.Influence of time on the results of reperfusion therapy (primary percutaneous coronary intervention) in patients with acute myocardial infarction with ST segment elevation

The aim – to determine the dependence of the mortality in acute myocardial infarction patients with ST elevation on time from onset of the disease to the restoration of myocardial perfusion using primary percutaneous coronary intervention (PCI).

Material and methods. A total of 421 patients underwent reperfusion therapy with primary PCI. Depending on the time of reperfusion, the patients were divided into 3 groups: patients with primary PCI during first 2 hours after onset of the symptoms (group 1, 109 patients); patients with primary PCI between 2 to 4 hours (group 2, 195 patients); patients with PCI after 6 hours (group 3, 117 patients).

Results. It was found that absence or low degree of recovery of peripheral coronary blood flow by Blush scale were significantly more common in group 3 patients (44.4 %) compared with group 1 (11.9 %); Р<0.0001. This may explain higher mortality in group 3 compared to group 1 (8.60 and 1.96 %, respectively; Р<0.05 %). Conclusions. The maximum early reperfusion therapy improves angiographic myocardial perfusion parameters. This, in turn, reduces mortality in patients with acute myocardial infarction with ST segment elevation.

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