Thrombolytic therapy (ТТ) is preferable when timely and optimal percutaneous coronary intervention is not performed. ECG is a method of instrumental control of the effectiveness of thrombolytic therapy. However, in the case of iatrogenic complications before the completion of the drug infusion assessment of the impact of the thrombolytic infusion is not carried out. Therefore the use of vectorcardiography (VCG) in addition to ECG makes it possible to objectify the results of ТТ. The paper includes clinical case of the patient with damage of the posteriorinferior wall of left ventricle confirmed by ECG. During the VCGstudy signs of abnormalities of coronary blood circulation at anterior wall and basal regions of ventricles as well as at the area of apex were detected. Furthermore, the overload of ventricles due to intact area of the myocardium and hemodynamic overload of atriums with disorder of the processes of repolarization at posteriorlateral region of left atrium and posterior wall of right atrium were recorded. On the 8th day of the disease high symmetrical T waves were recorded; VCGdata showed disorders of repolarization at the posteriorinferior wall. In general, the use of the VCG makes possible a detailed analysis of electromotive forces of heart in patients with acute coronary pathology even after unfinished TT when ECG is not informative.