V.P. Ivanov, Yu.V. Savitska Сhanges of N-terminal pro-brain natriuretic peptide in patients with chronic heart failure depending of quality of life parameters

The aim – to determine the level of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with systolic chronic heart failure (CHF) depending on quality of life (QoL) parameters by MHFLQ and SF-36 questionnaires.

Material and methods. There were examined 113 patients aged 60.20±0.74 years with systolic CHF of ischemic and hypertensive etiology. Depending on QoL indicators (total score by MHFLQ, physical (PH) and mental (MH) component of SF-36 questionnaire) the patients were divided into groups with relatively low (RL), relatively satisfactory (RS) and relatively high (RH) levels of QoL. The serum level of NT-proBNP was determined by ELISA.

Results. Levels of NT-proBNP ranged from 904 to 3836 pg/ml (in average – 1977.5±88.8 pg/ml). Analysis of the level of NT-proBNP depending on QoL by MHFLQ showed that in the group of RL (total score ≥ 61) QoL the level of biomarker and the number of patients with high level (> 2130 pg/ml) of NT-proBNP are higher than ​​in groups with relatively satisfactory (60-41 points) and relatively high (≤ 40 points) QoL (2552 pg/ml versus 1880 and 1650 pg/ml, respectively, Р<0.009 and 51.6 % against 22.6 % and 25.8 %, respectively, Р<0,04). Similarly the level of NT-proBNP was related to QoL by SF-36 questionnaire. Conclusions. It was shown that in patients with systolic HF II-III NYHA class of ischemic and hypertensive etiology level of NT-proBNP was, to some extent, associated with QoL by MHFLQ, PH and MH by SF-36 questionnaire.

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