M.P. Kopytsya, О.V. Petyunina Factors influencing the level of sST2 in patients with ST segment elevation myocardial infarction

The aim – to study the influence of different factors on sST2 level in patients with ST segment elevation myocardial infarction.

Material and methods. The study involved 65 patients with ST segment elevation myocardial infarction, 54 (83.1 %) men and 11 (26.9 %) women, average age 57.0±30.5 years. All patients were hospitalized on the first day after stenting of infarct-related coronary artery. ST2 was detected by immune fermentation method. Its level less then 35 ng/ml was regarded as normal.

Results. All patient revealed positive correlation between sST2 level and heart rate (r=0.25; Р=0.05), left ventricular diastolic diameter (r=0.31; Р=0.03), left ventricular systolic diameter (r=0.38; Р=0.007) and negative – with left ventricular ejection fraction (r=–0.48; Р=0.0001). In the regressive model (Р<0.05), the level of ST2 was caused by low ejection fraction (20.64 %; Р=0.0001), angina pectoris before index event (11.03 %; Р=0.01), female gender (9.96 %; Р=0.01), low HDL-C (8.54 %; Р=0.05) and high level of creatinine (7.83 %; Р=0.046). Conclusions. Received data show influence of sST2 upon left ventricular remodeling early after ST segment elevation myocardial infarction. Incremental regressive analysis allows to assess the influence of different factors on the sST2 level.

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