The infectious endocarditis (IE) is associated with high death rate and frequent development of heavy complications, despite improvement of the diagnosis and treatment. During recent years the changes of epidemiology characteristics of IE took place. The factors which were earlier not considered important receive a special value in the etiology of IE as a result of the larger risk of bacteriemia, i.e. degenerative changes, valve prostheses, abuse of intravenous usage of medications and drugs, growth of the number of invasive procedures. In this regard there are more cases of associated with medical interventions and less role of streptococcus as an etiological factor. The Working Group on Myocardial, Pericardial and Endocardial and Valve Diseases of the Ukrainian Association of Cardiology revised classification of IE, taking into account recommendations of ESC, 2009. Greater possibilities of visualization of heart, especially by MRI are highlighted in the guidelines. The idea of multidisciplinary approach received subsequent development in the renewed guidelines. The diagnosis and treatment of patients the with IE in the specialized centers by expert groups («the team of endocarditis») is recommended.