O.І. Mitchenko, V.Yu. Romanov, O.Yu. Kulyk, G.O. Shkroba.Leptin resistance in patients with essential hypertension and metabolic syndrome

The aim – to study levels of leptin and soluble leptin receptors (sOB-R) depending on carbohydrate disorders and body mass index (BMI) in patients with arterial hypertension (AH) and metabolic syndrome (MS).
Material and methods. Eighty patients (pts) with AH and MS have been included. They were divided into four groups:
1 group – pts with AH and MS without carbohydrate disorders; 2 group – pts with AH and insulin resistance (IR) without diabetes mellitus (DM) and impaired glucose tolerance (IGT); 3 group – pts with AH and IGT; 4 group – pts with AH and DM. We used the following methods: calculation of body mass index and waist circumference, blood pressure monitoring, echocardiography, fasting levels of sOB-R, leptin, glucose, insulin, definition of HOMA index.
Results. changes of leptin levels and sOB-R depending on carbohydrate disorders and body mass index were revealed in all groups. The pts of 4 group had higher leptin levels compared to 1 group. Carbohydrate disorders were associated with increase of abdominal obesity, leptin levels and reduced concentration of sOB-R. At the same time, sOB-R levels were inversely related to the degree of carbohydrate disorders.
Conclusions. Increased abdominal obesity was associated with increased leptin levels and reduced concentration of sOB-R receptors that is accompanied by occurrence of carbohydrate disorders.

Full article