L.E. Lobach, V.E. Dosenko, M.М. Dolzhenko Influence of aldosterone synthetase (CYP11B2) gene polymorphism upon the risk of myocardial infarction

The aim – to determine the effect of certain variant of aldosterone synthase gene polymorphism (CYP11B2) upon the risk of myocardial infarction (MI) in postinfarction patients compared to the patients with stable coronary heart disease without previous MI, patients at high cardiovascular risk and healthy volunteers.

Material and methods. 378 subjects examined by general clinical methods were divided into four groups: 100 patients with postinfarction cardiosclerosis, 78 patients with coronary artery disease without a history of heart attack, 100 high cardiovascular risk patients and 100 healthy subjects. Genetic testing was performed by polymerase chain reaction in real time. The comparison of groups was performed regarding aldosterone synthase (CYP11B2) gene polymorphism.

Results. During genotyping CYP11B2 –344C/T polymorphism in postinfarction patients the following relationship was shown: TT homozygotes, TC heterozygotes and CC homozygotes – 33; 50 and 12 %, respectively. CC variant of gene polymorphism CYP11B2 showed the lowest risk of myocardial infarction compared to TT + TC, while comparing postinfarction patients to healthy volunteers (Р=0.01).

Conclusion. We demonstrated the increased risk of myocardial infarction in postinfarction patients with TT + TC polymorphism of aldosterone synthase gene (CYP11B2).

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