M.I. Lutay, on behalf of the TRIUMF multicenter study group. Efficiency of the combined treatment of arterial hypertension in Ukraine: results of the TRIUMF multicenter study

The aim of investigation – to evaluate blood pressure (BP) control in the general population of patients with arterial hypertension (AH) during outpatient follow-up depending on number of antihypertensive drugs, to study the profile of patients with AH receiving two or three antihypertensive drugs.
Маterial and methods. Multicenter prospective study TRIUMF (Antihypertensive therapy in Ukraine – optimization of blood pressure in focus) was performed since 14.12.2015 to 02.04.2016. Among 3953 screened patients, 2772 received two or three antihypertensive drugs (70.1 %) by anamnesis data. In 82 % (n=2271) of them BP was higher than target. In 1213 patients triple fixed combination perindopril/indapamide/amlodipine was recommended, 143 (11.8 %) patients in addition to mentioned triple combination continued receiving β-blocker without change of the dosage.
Results. In 2 months of the recommended treatment systolic BP decreased from 169.27 to 133.15 mm Hg, diastolic BP – from 97.87 to 82.78 mm Hg (Р<0.001). After transfer to triple fixed combination target BP was achieved in 1120 (94.04 %) patients. Decrease of BP didn’t depend on initial BP, was statistically significant in all subgroups, independent on the initial therapy. The therapy was interrupted in 12 (1 %) patients due to side effects. The patients evaluated their satisfaction with treatment at 9.2 points (the highest score is 10 points). Conclusions. Switching to original triple combination of perindopril, amlodipine and indapamide significantly increases efficiency of antihypertensive therapy, making possible to achieve BP control in 94 % patients previously uncontrolled on two or three antihypertensive agents. Decrease of BP was achieved in all subgroups of patients, independent on the initial BP level.

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