Yu.V. Marushko, T.I. Gavrylenko, T.V. Hyschak, O.A. Pidgaina. Results of the study of endothelium vasoconstriction and vasodilation factors in children with primary arterial hypertension.

The aim – to investigate the serum contents of thromboxane B2 and 6-ketoprostaglandin F1α (6-keto-PGF1α) and their relationship with indices of blood pressure daily monitoring in children with primary arterial hypertension (PAH).

Materials and methods. The study involved 83 children aged 9 to 17 years. The first group included 32 children with stable PAH, the second – 32 children with labile PAH, the third (control group) – 21 children with normal blood pressure. The level of thromboxane B2 and 6-keto-PGF1α in serum was investigated by ELISA. All children were held ambulatory blood pressure monitoring.

Results. Average thromboxane B2 level in boys was 25.05±6.43 ng/ml at stable PAH and 27.26±11.26 ng/ml at labile PAH, which exceeded the parameters in the control group (P<0.05). Girls’ thromboxane B2 level was elevated in labile PAH (to 11.06±1.79 ng/ml, P<0.05) and did not differ from the control group in stable PAH. Girls level 6-keto-PGF1α was up to 3.41±0.52 ng/ml at stable PAH and up to 2.63±0.25 ng/ml at labile PAH. Conclusion. Changes of the ratio between endothelial vasoconstriction (thromboxane) and vasodilatation (prostacyclin) factors in boys with PAH is due to increase of thromboxane B2 level compared to children with normal blood pressure (P<0.05). Girls with PAH have better compensatory vasodilation possibilities compared to boys, showed by increased prostacyclin production. That prevents the progression of endothelial dysfunction and PAH stabilization in girls.

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