The article reviews contemporary data regarding main mechanisms of the development of metabolic syndrome (MS) and its role as a predictor of cardiovascular diseases. Pathogenetic relationships between components of MS, their separate and combined action, are described in details. Special attention is paid to low intensity systemic inflammation as a possible cause-factor of development and progression of MS. Besides, a review of pathogenetic treatment methods is provided. It is obvious that further investigations may be helpful in formation of new effective approaches in correction of metabolic disorders and prevention of clinical manifestation of coronary artery disease.