The blood levels of NO and it metabolites were determined in essential hypertension (EH) pts depending on clinical features of the disease and endothelium-dependent vasodilatation. 67 pts (46 men and 21 women) with
mild and moderate hypertension, middle age of (53.43±4.96) years and EH anamnesis of (6.93±2.40) years were observed. No clinical signs of ischemic heart disease or other diseases, requiring drug treatment, were
revealed. All pts underwent physical examination, standard clinical investigation, 24-h ambulatory blood pressure (BP) monitoring, echocardiography, determination of blood NO stable metabolites. All pts demonstrated increase of blood general NO, nitrit- and nitrate-anions accordingly by 56; 39 and 68 %, that directly correlated with left ventricular mass index and general carotid intima-media thickness and in inverse ratio – with
office diastolic BP and peripheral resistance. There was a reliable increase of blood NO metabolites levels due to nitrite-anionic complex in EH pts with damaged endothelium-dependent vasodilatation. The EH pts with “nondipper” and “over-dipper” 24-h BP monitoring type demonstrated more expressed left ventricular hypertrophy with tendency to the NO metabolites level increase due to a nitrite-anion compared to a “dipper” type. Pts with considerable, more than 35 mcmol/l of blood NO metabolites level demonstrated reliable increase of left ventricular volumes and tendency to worsening of diastolic function.