E.F. Barinov, O.N. Sulaieva, N.N. Kanana, K.I. GatinaMolecular mechanisms of functioning and role of P2Y1 and P2Y12 receptors in thrombogenesis.

M. Gorky Donetsk National Medical University, Ukraine
The role of purine platelet receptors (P2Y1 and P2Y12) in thrombogenesis under normal conditions and in cardiovascular pathology is reviewed. The intracellular signaling mechanisms associated with P2Y1 and P2Y12 receptors and biological effects of purines (ADP) on platelets are discussed. The role of genetic polymorphism, receptor sensitivity and mechanisms of receptor desensitization in platelet reactivity are addressed.

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