E.G. Nesukay, О.О. Danilenko, A.S. Kozliuk, S.V. Cherniuk, V.A. Fedkiv. Amyloidosis: clinical features, diagnosis and treatment

The article reviews contemporary diagnosis and treatment of cardiac amyloidosis. Amyloidosis is a group of diseases characterized by deposition of the special protein amyloid or its precursors in organs and tissues. The heart involvement is typical in AL-amyloidosis, secondary systemic amyloidosis, senile systemic amyloidosis, isolated atrial amyloidosis, familial amyloidosis. The article covers the issues of clinical presentation and diagnostic criteria for different types of cardiac and extracardiac amyloidosis. Typical cardiac manifestations of the diseases which may be detected by echocardiography, speckle-tracking echocardiography, cardiac MRI and laboratory diagnostics are discussed in detail. Much attention is paid to etiopathogenetic treatment of different types of amyloidosis. The experience of authors regarding management of cardiac amyloidosis is presented.

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