O.G. Obertynska. Resistant hypertension: analysis of multi-combination antihypertensive therapy

The aim – to analyze the efficiency of multi-combination antihypertensive therapy in patients with resistant hypertension.

Materials and methods. The work is based on the analysis of the treatment of 47 patients with treatment-resistant hypertension, among them 24 men and 23 women. The mean age of patients was 56.03±0.38 years. We studied medication history, regularity of drug intake, the drugs dosage.

Results. Among diuretics, patients with resistant hypertension mostly used hydrochlorothiazide – 81 % cases, indapamide – 15 %, torasemide – only 2 %. Aldosterone antagonists were used only in 2 % patients, although their efficiency has been proven irrespective of hyperaldosteronism. Together with diuretics, angiotensin converting enzyme were prescribed most often – in 89 % cases, including mostly enalapril and lisinopril, rarely – ramipril and perindopril. The percentage of β-blockers usage was high (about 75 % patients), with rare usage of β-blockers with vasodilator effect (carvedilol and nebivolol). Dihydropyridine calcium antagonists were used in 40 % of patients, most often amlodipine, much less – nitrendipine and nifedipine. Angiotensin II receptor blockers were used only in 4,2 % cases.

Conclusions. Resistant course of AH is more common in patients receiving the combination of diuretics (mainly thiazide), ACE inhibitors and β-blockers (60 % of cases). Thus, this combination might be less effective than others.

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