The aim of the research was to study the effects of the most used antiarrhythmic drugs on the prevalence of different types of orthostatic reactions (OR) of diastolic blood pressure (DBP) in patients with permanent form of AF under therapy. Seventy seven patients (35 females and 42 males) of middle age (67,9±10 years) with permanent form of AF have been studied. Sixty five patients had arterial hypertension, 56 – ischemic heart disease. Patients with IV functional class of stable angina, acute coronary syndrome, IV functional class of heart failure have been excluded from the study. Hypertensive OR of DBP has been determined as 5 % and more increase of DBP during orthostatic test. Isotensive OR of DBP has been determined as less than 5 % increase or decrease of DBP during orthostatic test. Hypotensive OR of DBP has been determined as 5 % and more
decrease of DBP during orthostatic test. Qualified OR of DBP has been determined as 20 % and more increase or decrease of DBP in orthostatic test. Hypotensive OR of DBP appears as the independent predictor of
cardiovascular death, hypertensive OR of DBP play a role in the prevalence of “mute” cerebral strokes, isotensive OR of DBP are connected with worse course of arterial hypertension. Yet, hypertensive OR are
considered as the most favorable. Isotensive OR of DBP are more prevalent (43 %) than hypotensive (36 %) and hypertensive (21 %) OR of DBP before the start of the therapy. Increase of hypertensive OR prevalence was
noticed under antiarrhythmic therapy with betablockers, amiodarone and digoxine.