V.O. Shumakov, T.V. Talayeva, L.P. Tereshkevych, I.E. MalynovskaPeculiarities of clinical course of postinfarction period under influence of angiotensin-converting enzyme inhibitors

Angiotensin-converting enzyme inhibitors (ACEI) play an important role in the contemporary treatment of myocardial infarction (MI) due to their influence on left ventricle remodeling and prevention of heart failure, as well as their pleiotropic effects. One hundred twenty patients with myocardial infarction were divided into three groups depending on usage of enalapril, perindopril or those who did not receive angiotensin-converting
enzyme inhibitors. The duration of follow-up was 6 months. Relationship between disturbances of lipid and carbohydrate metabolism, activity of system inflammation, endothelial dysfunction, carotid arteries intimamedia thickness, hemodynamic parameters by echocardiography and exercise tolerance was found. The positive influence of ACEI, especially perindopril, at above-mentioned indices was established.

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