A.I. Dyadyk, V.K. Grin, A.S. Vorobyov, O.I. Stolika, N.Yu. Tsyba, S.V. Maltsev, A.E. Bagriy, E.V. Schukina, V.B. Kostogryz Evaluation of the markers of myocardial stress activity for prognosis of postinfarction left ventricular remodeling

Prognosis of post-myocardial infarction (post-MI) outcomes is of great importance and remains a highly controversial topic. Significant place in prognosis of post-MI left ventricular (LV) remodelling is assigned to the markers of myocardial stress. We investigated 46 patients having Q-wave MI. Serum levels of NT-proBNP were measured at 2–7 days of MI. During 4–18 months of post-MI period echo-derived parameters of LV dilatation
and systolic dysfunction were estimated. Our results demonstrate significant correlations between levels of NT-proBNP and dynamic changes of LV structure and function during its post-MI remodelling. Serum levels of
NT-proBNP in an acute phase of Q-wave MI may be used for early detection of patients of the high risk to develop post-MI LV remodelling.

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