The purpose of the study was to examine survival of post myocardial infarction patients during 5-years follow-up and to define the detrimental predictors which substantially deteriorate it. Long-term follow-up was performed in 2 groups of pts: 1st (n=177) – 5-years follow-up and 2nd (n=329) – 2 years observation. Death outcome in 5 years follow-up group was observed in 9 % pts. More than 80 % of fatal cases were due to cardiac reason. The frequency of death cases was higher during first two years (5.2 %); reinfarctions appeared more often during first two years (4.5 %) compared to the last 3 years (2.3 %). Impairment of left ventricular systolic function (ejection fraction less than 45 %) was a major unfavourable predictor of survival during follow-up period. At same time, arterial hypertension and elevation of cholesterol level becomes a significant prognosis predictor during 5 years observation.