V.I. Tseluiko, T.R. Bregvadze, N.Ye. Mishchuk Parameters of daily blood pressure monitoring and target organ damage in ambulatory patients with arterial hypertension.

We have investigated the target organ damage in 100 patients with arterial hypertension aged 22 to 73 years. Complex investigation included electrocardiography, echocardiography (EchoCG), daily blood pressure
monitoring (DВPM) and determination of creatinine level with calculation of creatinine clearance. Relationship between the level of blood pressure at DBPM and left ventricular hypertrophy (LVH) has been proven – the
higher was blood pressure level, the more likely is LVH. In patients with LVH, EchoCG showed not only enlargement of left chambers, but also of right chambers. EchoCG indicators of LV function in this group of
patients were significantly worse than in patients without LVH. The only clinical distinction of patients with reduced creatinine clearance < 60 ml/min from a group of patients with normally functioning kidneys was age – it was significantly higher in the first group. No relationship was determined between the level of blood pressure and renal function, as well as between EchoCG parameters and renal impairment. There was correlation between the presence and degree of target organ damage and age. The higher the patient's age, the more likely is damage of target organs, as well as their combination.

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