L.A. Mishchenko Predictors of left ventricular hypertension in essential hypertensive patients.

Eighty four essential hypertensive patients were included into 5-year prospective study. Clinical examination, laboratory tests (blood creatinin, glucose, insulin, C-recative protein (CRP), uric acid and 24-hour urinary albumin excretion) and cardiac ultrasound were performed at the first and final visits. Analysis of the dynamics of structural left ventricular parameters in association with blood pressure and biochemical parameters shown that progression of left ventricular hypertrophy (LVH) occurs on a background of uncontrolled hypertension, deterioration of renal function and carbohydrate, lipid and purine metabolism, whereas regression of LVH is associated with effective control of blood pressure, stability of metabolic and pro-inflammatory indices and renal function in hypertensive patients. It is established that the original value of left ventricular mass index (LVMI), an increase albumin excretion and increased CRP levels at baseline were independent predictors of LVMI increase: risk of development and progression of LVH increased by 2.9-fold in the presence of microalbuminuria, and by two times with an increase of CRP levels over 4.2 mmol/l.

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