The article discussed issues of secondary resistance to acetylsalicylic acid that is especially dangerous in patients needing continuous antiplatelet therapy. A retrospective analysis of medical records of patients who developed aspirin resistance, has been conducted, Risk factors have been identified that have the greatest impact on the development of this phenomenon. Predictors of the development of secondary aspirin resistance
have been identified: a high (more than 7.0 mmol/L) cholesterol level in blood plasma; presence of diabetes mellitus; a glucose level above 8.5 mmol/L both in patients with a history of diabetes and in other persons with
newly detected hyperglycemia; left ventricular ejection fraction under 55%; smoking of more than 10 cigarettes a day; a disturbed blood flow in microvessels (a microcirculation index less than 1.1 ml/min) and a level of endothelium-dependent vasodilation under 4.0 ml/min-1/100 g.