In order to study the predicted survival rate during 1st, 2nd, 3rd and 5th years depending on the total score indices of the Minnesota Living with Heart Failure Questionnaire (MLHFQ), 554 patients with chronic heart failure of III functional class NYHA were evaluated. During the first stage of the research by means of cluster analysis (k-average method) the sub-groups of patients were selected, which were non-overlapping regarding the total score indices of MLHFQ and at the same time were definitely distinct regarding cumulative survival during 1st, 2nd, 3rd and 5th years. The indicated sub-groups were homogeneous as to the value of left ventricular ejection fraction, frequency of treatment with angiotensin converting enzyme inhibitors, beta-adrenoreceptor blockers and gender distribution. During the second stage the relative risk was calculated by Cox regression of fatal events for the patient clusters within range of values of overall life quality index, which was associated with reliable worse survival during each of the given investigation period. The long-term survival of chronic heart failure patients found out its dependence on the overall index of the MLHFQ. The overall score of MLHFQ ≥ 69 is the survival predicting factor for patients with chronic heart failure of III functional class NYHA during 1–5th years of observation irrespectively of the value of left ventricular ejection fraction, usage of angiotensin converting enzyme inhibitors and beta-adrenoreceptor blockers, and gender distribution. The above-mentioned predicting factor is the most comprehensive in predicting fatal events during next 12 months and proportionally decreases with longer follow-up period (1–5 years).