Atherosclerosis is a chronic disease, which arises as result of metabolism changes and injury of elastic and muscular-elastic type arteries. There are many theories and hypotheses of atherosclerosis development.
According to the first theory, the principal cause of atherosclerosis is deposition of lipids in vascular wall. Another hypothesis consists of mechanical, chemical, immunological injury of the vascular wall, including endothelium. In our work we study influence of mechanical injury of coronary artery wall as result of using one of direct methods of myocardial revascularization (coronary bypass with and without extracorporeal circulation, coronary stenting) for further progress of coronary artery atherosclerosis. The issue of angina pectoris recurrence in patients with chronic coronary artery disease after coronary bypass or stenting remains the problem of today, because these methods can’t block atherosclerosis progress. In our article we show possible mechanism and localization of endothelium injuries of coronary artery by achievement of different interventions: coronary bypass (with and without extracorporeal circulation) and stenting.