The aim of study was to evaluate factors related to the compliance and its changes during antihypertensive treatment. We included 10 158 hypertensive patients, which were treated by 531 general practice physicians.
Physicians administered antihypertensive therapy based on domestic generic drugs (bisoprolol, enalapril, fixed combination enalapril+hydrochlorthiazide, amlodipine) during 3 months. Four visits have been performed with
evaluation of office blood pressure and heart rate, ECG patterns, compliance (by questionnaire). It was stated that 43.2 % hypertensive patients had low (< 50 % taking prescribed drugs) compliance at baseline. Factors associated with poor compliance were older age, presence of coronary heart disease or such complications as myocardial infarction, stroke or heart failure, lifestyle (higher body mass index, smoking, alcohol abusing, low physical activity, low consumption of fresh fruits and vegetables, high salt consumption), low education and absence of work (or retiring). The level of blood pressure was higher in patients with baseline low compliance at all 4 visits. The target blood pressure was not achieved in 33.5 % patients with high compliance, in 39.9 % with baseline moderate compliance (P<0.001 vs high) and in 47.6 % (P<0.001 vs high and 0.005 with moderate) with low baseline compliance. In 61.7 % patients, who took antihypertensive treatment based on domestic generics we noted improving of the compliance. Improving of compliance depended on baseline patient condition (presence of complications and concomitant disease) and prescribed therapy (lowering blood pressure, choice of therapy, quantity of drugs, presence of adverse reactions). Impairment of compliance depended on lifestyle modification and blood pressure lowering.