O.S. Sychov, A.O. Borodai, S.V. Fedkiv, E.S. Borodai.Quality of life, anxiety, depression and cognitive impairment in patients with non-valvular atrial fibrillation and silent cerebral infarctions

The aim – to analyze quality of life (Qol), rate of anxiety, depression and cognitive dysfunction in patients with persistent atrial fibrillation (AF) and to evaluate their relationship with clinical, echocardiographic predictors and silent cerebral infarctions (SCI).

Material and methods. In prospective cross-sectional study we examined 101 patients with non-valvular AF without history of prior stroke.

Results. SCI were detected in 34.7 % of patients, superficial SCI in 10.9 % of cases, basal SCI in 23.8 % and SCI ≥ 15 mm in 7.9 % of patients. Mean physical HeartQol (HeartQol phys) subscale score was 1.6±0.8, emotional (HeartQol em) 2.0±0.9. By HADS anxiety subscale (HADS А) mean score was 5.8±3.0, and mean depression (HADS D) score was 4.1±3.1. The self reported EHRA score was 2.5±0.8, and mean MMSE score 27.7±1.9. Anxiety (HADS А > 7) – 22.8 %, depression (HADS D > 7) – 16.8 %, low level of both physical (HeartQol phys < 2) – 61.4 % and emotional (HeartQol em < 2) – 40.6 % aspects of QoL and cognitive impairment (MMSE ≤ 25) in 14.6 % were found in patients with AF. Conclusions. Anxiety, depressive disorders, decreased quality of life and cognitive impairment were often found in study patients. Female gender, depression, and self-reported AF-specific symptoms severity were independent predictors of low physical and general QoL. Low left ventricular systolic function was an independent predictor of physical QoL, but was not associated with general QoL and emotional disturbances in the study patients.

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