National Scientific Center “M.D. Strazhesko Institute of Cardiology NAMS of Ukraine”, Kyiv, Ukraine
The morphological and functional alteration of microcirculation was studied in myocardial biopsies, performed in patients with ischemic heart disease without diabetes mellitus and myocardial infarction. The degree of stenosis of the coronary arteries was 80–90 % in proximal segment. The specimens of myocardial tissue were received from the ischemic area and outside zones. The research was carried out with use of semi-thin cut and studies with microscopic and morphometric methods. It was discovered that adaptation and pathological changes іn microvessels were widespread and played role in the limitation of coronary reserve, presenting a structural basis for coronary X syndrome. Without regard to stereotype character of these changes, more expressed reduction of trophic segment of microcirculation and different ratio of reverse and permanent violations lead to morphologic differences in ischemic and nonischemic zones.